International Journal of Medical and Biomedical Studies 2022-06-26T07:06:24-04:00 IJMBS Open Journal Systems <p><strong>Aims and Scope</strong></p> <p>International Journal of Medical and Biomedical Studies&nbsp;(IJMBS) is an international, peer-reviewed, open access, online journal dedicated to the rapid publication of full-length original research papers, short communications, invited reviews, Case studies and editorial commentary and news, Opinions &amp; Perspectives and Book Reviews written at the invitation of the Editor in all areas of the Medical and Biomedical Studies.</p> <p>International Journal of Medical and Biomedical Studies&nbsp;is an academic journal which aims to publish complete and reliable source of information in the field of medical research providing the fundamental knowledge for further research.&nbsp;<em>IJMBS</em>&nbsp;commits to publish the results of researches in medical practice, risk factors and preventive medicine, safety and effectiveness of treatments, and diagnostic tools that are used to treat any disease. 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In oligohydramnios group 90.8%babies were healthy while8.4%were died in NICU and0.8% were still birth while in polyhydramnios group 76% babies were healthy while 4% were died in NICU and20%babies were still birth. Still birth rate in very high in polyhydramnios group. This difference was found statistically highly significant (p&lt;0.001).</p> <p style="font-weight: 400;"><strong>Conclusion:</strong> Development of abnormal liquor volume during pregnancy signals danger to the foetus. It is associated with an increased incidence of caesarean section, labour complications and adverse perinatal outcome. But isolated oligo and polyhydramnios in term gestation has better perinatal outcome compared to early onset and with associated conditions like hypertensive diseases of pregnancy, GDM, IUGR. Ultrasound is the ideal method to detect any abnormality in liquor volume. If any abnormality is detected during the ultrasound, a careful search should be made to detect any identifiable congenital anomalies.</p> <p><strong>Keywords:</strong> Oligohydramnios,&nbsp; Polyhydramnios, Fetomaternal</p> 2022-06-05T00:00:00-04:00 Copyright (c) 2022 International Journal of Medical and Biomedical Studies Variation of Platelet Indices in Sepsis 2022-06-26T07:06:24-04:00 Shivani Sharma Kavita Sharma Vanita Kumar <p style="font-weight: 400;"><strong>Introduction</strong>: Almost every organ can be affected in the case of sepsis. In fact, the hemostatic system has also been known to be adversely affected in case of sepsis. Platelet indices are cheap and readily accessible, laboratory parameters that can be used to assess the severity of sepsis.</p> <p style="font-weight: 400;">Aims and objectives- This study was aimed at comparing the parameters of platelet indices in patients with fever and sepsis leading to multiorgan dysfunction.</p> <p style="font-weight: 400;"><strong>Materials and methods</strong>: This was a hospital-based cross-sectional study conducted in our pathology department in patients admitted with sepsis in the medicine in-patient department over 1 year. Inclusion criteria were patients with sepsis. Two ml of blood was withdrawn from the antecubital vein of the cases and samples were collected in an EDTA vial, which was kept at room temperature on day 1 and day 7 of admission. The complete hemogram reports were analyzed. The collected data was recorded on a prestructured proforma.</p> <p style="font-weight: 400;"><strong>Results</strong>: This study included 100 serially recruited patients having sepsis. The mean age of cases was 48.3 ± 16.3 years. While 63% of cases were male, 37% were females. The rise of PDW from day 1 to day 7 was statistically insignificant (p value= 0.24). However, the plateletcrit (PCT) fell significantly from day 1 to day 7 (p value=0.02). In our study, there were 76% survivors and 24% non-survivors. Platelet volume (MPV) rose significantly (p value=0.01), and TC fell significantly (p value&lt;0.0001). Similarly, the platelet count also fell significantly (p value&lt;0.05).</p> <p><strong>Conclusion:</strong> Platelet indices, especially MPV, PDW, and platelet count are reliable indicators of sepsis prognosis.</p> 2022-06-26T00:00:00-04:00 Copyright (c) 2022 International Journal of Medical and Biomedical Studies Treatment for Plantar Fasciitis using Platelet Rich Plasma (PRP) 2022-06-18T09:18:10-04:00 Naveen Meena Mohit Kumar Tejwani Rajesh Goel <p style="font-weight: 400;"><strong>Objective:</strong> Case series aimed to evaluate clinical outcome of patients&nbsp; who underwent treatment for plantar fasciitis using Platelet rich plasma (PRP).</p> <p style="font-weight: 400;"><strong>Method:</strong> Patients were diagnosed clinically who presented with plantar inferio-medial heel pain longer than 6 weeks. All patients were injected with freshly prepared 2ml of PRP injection at heel medial entry point with direction towards the tendor point. The patients were followed up clinically and functionally at 2 weeks, 4 weeks, 3 months and 6 months. VAS score and American orthopaedic foot ankle score was used to assess the patients.</p> <p style="font-weight: 400;"><strong>Result:</strong> Total 60 patients were included in the study (39 female and 21 male).The average age in the series was 43.07 years ± 6.73.Mean VAS scoring at 6 months of follow up was 1.9(SD1.5).The mean AOFAS scoring at the end of 6 month of follow up was 90(SD7.54).</p> <p style="font-weight: 400;"><strong>Conclusion:</strong> Platelet Rich Plasma Injection technique for plantar fasciitis offers a better treatment with (1) its application is minimally traumatic,(2) it has a reduced risk for immune mediated rejection, devoid of potential complications such as hypoglycemia, skin atrophy, tendon tears associated with corticosteroid injection, (3) it is simple to acquire and prep are,easy to carry out as out patient procedure and(4) it is inexpensive,(5) better relief of pain,(6) lower currencerate</p> <p><strong>Keywords:</strong> VAS, AOFAS, orthopaedic</p> 2022-06-27T00:00:00-04:00 Copyright (c) 2022 International Journal of Medical and Biomedical Studies Study of Minerals and Trace Elements in Hypothyroidism Patients 2022-06-24T08:02:38-04:00 Varsha Chowdhry Deepa . Harshvardhan Avinash Bairwa <p style="font-weight: 400;"><strong>Background: </strong>Thyroid hormones, by their direct action on bone turnover, play a significant role in calcium and phosphorus homeostasis. This study was important because thyroid hormones play a role in calcium and phosphorous metabolism, which is often disrupted in thyroid dysfunction. In thyroid disease, it's important to keep an eye on increases in serum calcium and phosphorus levels. The aim of this study is to compare the levels of serum calcium and phosphorus in hypothyroidism patients to those in apparently safe controls. Iodine, selenium, copper, zinc, and other trace minerals can interfere with the correct production and metabolism of thyroid hormones.</p> <p style="font-weight: 400;"><strong>Aim:</strong> Study of Minerals and Trace Elements in Hypothyroidism Patients.</p> <p style="font-weight: 400;"><strong>Material and Method</strong>: Between February 2020 and March 2021, a clinical-based case control&nbsp;study was performed. A research group of 100 hypothyroid patients from the JLN Medical College and Hospital in Ajmer, Rajasthan was compared to a control group of 100 seemingly healthy people. Blood samples were taken from the classes, and serum calcium, phosphorus, magnesium, Copper (Cu), Zinc (Zn) and Selenium (Se) levels were estimated.</p> <p style="font-weight: 400;"><strong>Results: </strong>The findings indicate a significant decrease in mean serum calcium levels in the test group compared to the control group and a significant increase in mean serum phosphorus levels in the test group compared to the control group in this sample. When compared to controls, serum magnesium levels were significantly higher with mean values.</p> <p style="font-weight: 400;"><strong>Conclusion: </strong>In hypothyroid disorders, serum calcium and phosphorus levels are substantially altered. The levels of these minerals should be tested in hypothyroidism patients. The trace elements played a part in several metabolic processes as either necessary nutrients or as cofactors for various enzymes, which either directly or indirectly caused hypothyroidism. As a consequence, the findings of this study indicate that selenium, manganese, and zinc metabolism in hypothyroidism condition is aberrant.</p> <p><strong>Keywords</strong>: Thyroid stimulating hormone, Calcium, Phosphorus, Magnesium and Trace elements</p> 2022-06-24T00:00:00-04:00 Copyright (c) 2022 International Journal of Medical and Biomedical Studies Clinical Profile of Ectopic Pregnancy 2022-06-15T10:45:33-04:00 Savitri Sharma Arti Bai Aditya Rathore <p style="font-weight: 400;"><strong>Background:</strong> A ruptured ectopic pregnancy is a true emergency and remains the leading cause of pregnancy related first trimester deaths.</p> <p style="font-weight: 400;"><strong>Methods:</strong> Hospital based Retrospective study conducted on women who presented to our hospital with ectopic pregnancy were analysed from the available hospital documents (bedside records, history, operation theatre records and yearly audit report).</p> <p style="font-weight: 400;"><strong>Results:</strong> The mean age - 27 ± 3&nbsp;&nbsp; years.The majority of patients (47.36%) were within the age group 25–29years. A significant proportion (53%) of these were multiparous, while only 26.31%were nuliparous. Majority of the patients had amenorrhea of ?7 weeks. The commonest site of ectopic gestation was the ampullary region while the tubo-ovarian site had the lowest occurrence.</p> <p style="font-weight: 400;"><strong>Conclusions:</strong> Ectopic pregnancy remains a gynecological emergency in developing countries and a major challenge to the reproductive performance of women worldwide, it should be considered a relevant public health issue in India</p> <p><strong>Keywords:</strong> Ectopic, Pregnancy, Amenorrhoea.</p> 2022-06-15T00:00:00-04:00 Copyright (c) 2022 International Journal of Medical and Biomedical Studies Recurrence of Inguinal Hernia after Open Mesh and Laparoscopic Repair Approach: A cumulative review 2022-06-10T07:04:57-04:00 Narendra Jangir I.D. Charan <p>Hernia repair is one of the most common surgeries performed worldwide which has a challenging aspect of recurrence as an irresistible problem besides the improvements in socio economical and technical factors. The recurrence rate depends upon the mode of primary repair also with skills of the surgeon. The factors lead to recurrence the most are technical, surgeon’s experience, family history and other patient related factors including heavy weight lifting and other medical complications. This is concluded in the review that open mesh repair have less recurrence of hernia than laparoscopic due to skills of the surgeon and it is also more practiced approach due to economical reason.</p> 2022-06-24T00:00:00-04:00 Copyright (c) 2022 International Journal of Medical and Biomedical Studies