STUDY OF EFFICACY OF METERED DOSE INHALER (MDI) AND DRY POWDER INHALER (DPI) FOR DELIVERY OF SALBUTAMOL IN TREATMENT OF ACUTE EXACERBATION OF ASTHMA IN PATIENTS, ATTENDING IN TERTIARY CARE HOSPITAL AT, PATNA

Abstract

Objective: Present study was undertaken to compare the efficacy of Metered dose inhaler (MDI) with spacer and with Dry powder inhaler (DPI) for delivery of salbutamol in acute exacerbation of bronchial asthma. It is a randomized controlled trial study.

Material and Methods: A total of 78 children in the age group of 6-14 years who presented with a mild or moderate acute exacerbation of asthma were included in the study. Salbutamol dose of 400µg were given to all the children’s by either a MDI with spacer or a DPI in randomized pattern. All the changes in the wheezing and accessory muscle scores, Sa02, and PEFR were noted.

Results: Out of 78 children, 42 were assigned to the MDI spacer group and 36 to rotahaler (DPI) group. After receiving treatment, the PEFR improved by about 14% in both the groups. The oxygen saturation increased by 2.1% in both the groups. Within each group, the improvement in PEFR, Sa02, wheeze and accessory muscle score after the treatment was statistically significant.

Conclusion: Metered dose inhaler with spacer and Dry powder inhaler are equally effective in delivering salbutamol in therapy of mild to moderate acute exacerbations of bronchial asthma in children between 6-14 years of age

Keyword: DPI, Salbutamol, Treatment, Asthma, Children, MDI, PEFR