CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF SUBSTITUTED BENZIMIDAZOLE DERIVATIVES

Abstract

A blend of 32.4 g (0.1 mole) of ortho phenylenediamine (OPD), 19.5g (0.1 mol) of Potassium hydroxide (KOH) and 26 g (0.1 mole) of carbon disulphide (CS2), 300 ml of 95% ethanol and water were taken in round base flagon and reflux give coupling prouct benzimidazole 2-thiol (1) was isolated as flicker white precious stone. 10.75ml of concentrated nitric corrosive and equivalent amount of concentrated sulphuric corrosive (1:1) was included The nitration item 5-nitro benzimidazole 2-thiol (2) was shaped as yellowish pale shading, at that point S-alkylated subordinates framed from 5-Niro benzimidazole 2-thiol utilizing acetonitrile (20 ml) containing 2 ml (14 mmol) DBU followed by the expansion of 0.72 g (5 mmol) of 2-diethylaminoethylchloride (3i), 4-aminobenzylchloride (3ii), 4-Hydroxybenzylchloride (3iii), 4-nitro 2-Hydroxybenzylchloride (3iv) give The arrangement was mixed for the time being at room temperature and the dissolvable vanished. Water (5 ml) was added to the buildup and the blend was carried to pH 7 with CH3COOH. The accelerate framed was sifted and solidified from H2O to give last item (3a), (3b), (3c), (3d) individually.

Keywords: Benzimidazole, Anti-microbial, S-Alkylation benzimidazole, 2- mercapto benzimidazole.