EVALUATE THE EFFICACY OF INSTILLATION OF INTRAVAGINAL PROSTAGLANDIN E2 GEL IN CERVICAL RIPENING: A COMPARATIVE STUDY.

Abstract

Aim: to evaluate the efficacy of instillation of intravaginal prostaglandin E2 gel in cervical ripening.

Materials and methods: The present prospective comparative interventional study was conducted in the Department of Obstetrics and Gynecology, Nalanda Medical College and Hospital, Patna, Bihar. Total 60 patients were divided in to two groups. Group I (n=30): received two doses of 2 mg prostaglandin gel intravaginally, 6 hours apart, Group II (n=30): received single dose of 2 mg prostaglandin gel intravaginally. After administering the gel into the posterior fornix under aseptic conditions the woman was kept on the bed for 30 minutes and was observed for contractions, rupture of membranes, bleeding or fetal heart rate changes. The patients were also assessed to determine the modified Bishop score.

Results: Both the groups were comparable in demographic factors like age and period of gestation. The most common indication for induction was past dates followed by gestational hypertension and Oligohydramnios.

Conclusion: The study showed that intravaginal application of prostaglandin E2 is an effective, safe and acceptable method for induction of labor in women with unfavorable cervix and indications for induction.

Keywords: prostaglandin E2, labor, gestational hypertension, vaginal delivery, Bishop score