VITAMIN D SUPPLEMENTATION AND ITS EFFECT ON PREGNANCY OUTCOME: A COMPARATIVE STUDY.

Abstract

Aim: to determine the effect of vitamin D supplementation on pregnancy outcome.

Materials and methods: The present prospective comparative interventional study was conducted in the Department of Obstetrics and Gynecology, Jawaharlal Nehru Medical College and Hospital, Bhagalpur,Bihar,India.  Total 80 patients were divided in to two groups. Group I (n=40): received only routine iron, folic acid and calcium supplementation (irrespective of vitamin D level). Group II (n=40): vitamin D supplementation (irrespective of vitamin D level) in the form of oral cholecalciferol sachet 60,000IU vitamin D weekly from 10 weeks of pregnancy until delivery along with routine iron, folic acid and calcium supplementation.

Results: Pre-eclampsia was observed in 22.5% of the patients who didn’t receive vitamin D supplement whereas the group I which received supplementation showed on pre-eclampsia in   6.7% of the patients (p=0.001).

Conclusion: This study concludes that there is significant role of vitamin D supplementation in pregnant women in prevention of pre-eclampsia.

Keywords: pre-eclampsia, vitamin D, singleton