STUDY TO COMPARE THE EFFICACY AND SAFETY OF ULIPRISTAL ACETATE AND MIFEPRISTONE AS MEDICAL TREATMENT OF UTERINE FIBROID.

Abstract

Uterine fibroids are one of the most common benign uterine tumors seen in females of reproductive age group. They either may be completely asymptomatic (diagnosed incidentally while doing ultrasound for some other reason) or may present as menorrhagia, lower abdominal or back pain, pelvic mass, obstructive uropathy, anemia secondary to blood loss and infertility. The management of uterine fibroids depends upon factors like possibility of pregnancy in future, whether preservation of uterus is desirable, severity and characteristics of symptoms. Various treatment options include observation and follow up, medical management (Mifepristone or Ulipristal acetate), uterine fibroid embolisation and hysterectomy. This study was done to know the effect of ulipristal acetate and mifepristone on Menstrual blood Loss, Dysmenorrhea, Uterine size & fibroid size. This was a comparative study done in 160 patients attending outpatient department of Obstetrics and Gynaecology of Patna Medical College and Hospital (PMCH). Treatment of symptomatic fibroids by Mifepristone as well as Ulipristal acetate was associated with reduction in fibroid size, reduced blood loss and decreased pain. We conclude from this study that both these drugs can be used for treatment of symptomatic fibroids

Keywords:  Uterine Fibroid, Ulipristal Acetate, Mifepristone