AMELIORATIVE EFFECTS OF POLYHERBAL EXTRACT ON HIGH FAT DIET HYPERLIPIDEMIA IN RATS

Abstract

Hypercholesterolemia is extremely common in the general population, is regarded as a high-risk factor for several health problems in this 21st century. This may be due to increased trends towards the western lifestyle and high cholesterol-rich diet intake. Drug based cholesterol control is a common norm in allopathic treatment, though there are several side effects. While many efficient lipid-lowering synthetic drugs exist, none is in effect for all lipoprotein disorders, and all such agents are accompanying with some adverse effects. The present study was intended to investigate the anti-hyperlipidemic activity of polyherbal extract in High Fat Diet (HFD) induced hyperlipidemia in wistar rats in an attempt to establish traditional use of the different components of this polyherbal extract. In hyperlipidemic rats, it has been observed that there is a gradual increase in the body weight of animals. Moreover, HFD fed group showed significant change in lipid profile and serum liver biomarker enzyme levels.  However, high dose of polyherbal extract showed significant improvement in liver biomarker enzyme levels, lipid profile and liver histopathology. In this study, the mechanism of action of polyherbal extract correlates with anti-hyperlipidemic drugs that decrease the synthesis of triglycerides which ultimately decreased the lipid level in blood. Hence, polyherbal extract (PHE) at higher dose (1500mg/kg) can be used to treat hyperlipidemia and related complications.