STUDY OF ANTIDIABETIC EFFECT OF POLYHERBAL EXTRACT IN ALLOXAN INDUCED DIABETIC RATS

Abstract

Diabetes mellitus is a metabolic disorder in which there is defect in insulin secretion high blood sugar levels over a prolonged period. The polyherbal extract under study contain extract of Eugenia jambolana (seed) , Citrulus colocynthis (fruit), Terminaliachebula ( Fruit) , Curcuma amada (Rhizome) , Syzigium cumini ( seed) in  combination shows decrease in levels enhace gluconeogenesis from protein and Amino acid with accumulation of glycogen in liver. Crude drugs like Eugenia jambolana, Mamordica charantia, Terminalia Chebula, and Black cumini increase secreation of insulin from B-cells of islets of pancrease. The proposed study is to investigate the effectiveness that of combination of these herbs as a polyherbal extract formulation in treatment of type II diabetic model. In the present study, experimental diabetes was induced Alloxan dose 150 mg/kg(Group ll), Diabetic standard diabetic rats were treated with oral dose of (metformin) 10mg/kg (Grouplll), group iv, v, vi) Diabetic rats were treated with an polyherbal extract 50mg/kg, 100mg/kg, 150mg /kg respectively. Drugs Metformin and polyherbal extract were given once in daily. The dietry regimen for 21 days, during which blood glucose level and lipid profile measured at 0,7,14,21 day of study using blood from rats retroorbital plexus. A high dose (200 mg/kg) of polyherbal extracts treatment group produce significant decrease in plasma glucose level.

Keywords: Diabetes, Eugenia jambolana, Citrulus colocynthis, Mamordica charantia, Gymnema stylvestre